Huntington's Disease is an inherited, ‘neuro-degenerative’ genetic brain disorder, affecting about 35,000 people in North America. There are another 150,000 at risk. The genetic flaw basically causes brain cells to start dying at around age 30.
This leads to a steady deterioration in both mental and physical abilities, including mood swings, cognitive impairment, loss of balance, speech, muscle control, and eventual total incapacitation.
Today there is no treatment. It always proves fatal, usually by the mid-40s.
An effective treatment is realistically within reach in the immediate future.